Abstract
There are limited reports on the effect of platelet-rich plasma (PRP) on meniscus healing. The purpose of this study was to investigate the effect of leukocyte-rich PRP (L-PRP) on potential healing of the horizontal medial meniscus tears in a rabbit model. A horizontal medial meniscus tear was created in both knees of nine skeletally mature adult rabbits. Left or right knees were randomly assigned to a L-PRP group, or a control group. 0.5 mL of L-PRP from 10 mL of each rabbit's whole blood was prepared and injected into the horizontal tears in a L-PRP group. None was applied to the horizontal tears in a control group. The histological assessment of meniscus healing was performed at two, four, and six weeks after surgery. We found that there were no significant differences of quantitative histologic scoring between two groups at 2, 4, and 6 weeks after surgery (p > 0.05). This study failed to show the positive effect of single injection of L-PRP on enhancing healing of the horizontal medial meniscus tears in a rabbit model. Single injection of L-PRP into horizontal meniscus tears may not effectively enhance healing of horizontal medial meniscus tears.
Highlights
Platelet-rich plasma (PRP) is a concentrated source of a variety of growth factors that may enhance the healing of the bone and soft tissue
There are four families of PRP products based on their fibrin architecture and leukocyte content: pure platelet-rich plasma (P-PRP) family, leukocyte- and platelet-rich plasma (L-PRP) family, pure platelet-rich fibrin (P-PRF) family, and leukocyte- and platelet-rich fibrin (L-PRF) family [5, 6]
leukocyte-rich PRP (L-PRP) may be an alternative method in delivering PRP into the inside of the meniscus, because LPRP is less thick than L-PRF
Summary
Platelet-rich plasma (PRP) is a concentrated source of a variety of growth factors that may enhance the healing of the bone and soft tissue. The L-PRF is found to release growth factors slowly over 7 days [7, 8], suggesting that the combination of leukocytes and final architecture of the fibrin matrix considerably influence the growth factor trapping and release. They help growth factors to act as an assembly of platelets and leucocytes in a complex fibrin matrix [9,10,11,12]. L-PRP may be an alternative method in delivering PRP into the inside of the meniscus, because LPRP is less thick than L-PRF
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