Abstract
Asthma is an inflammatory disease of the lungs, and it causes oxidative stress. Lavandula dentata is an aromatic herb with anti-oxidative and anti-inflammatory activities. This study examined the activity of L. dentata extract on a guinea pig model of asthma. Adult males were divided into five groups: First group was control, second was asthma model induced by OVA, third was treated with L. dentata extract orally (300 mg/kg) for 21 days; the fourth was an asthma model with L. dentata extract (300 mg/kg) and fifth was treated with Tween 80 for 21 days. OVA treatment increased IgE, triglycerides, total cholesterol, glucose levels in serum, WBC count in blood and MDA in lungs. Also, OVA reduced SOD activity, GSH content in lungs, and GGT activity in serum (p<0.05). L. dentata extract treatment in asthma model reduced elevated IgE, triglycerides, total cholesterol, glucose levels in serum, and MDA in lungs (p<0.05), while it increased GSH content in lungs (p<0.05). These results suggest the possibility that L . dentata extract can exert suppressive effects on asthma, and may provide evidence that it is a useful agent for the treatment of allergic airway disease, it also limits oxidative stress induced by OVA. L. dentata extract appears to have hypolipidemic and hypoglycemic activities.
Highlights
Asthma is a chronic disease defined by variable features, including reversible airways obstruction, airway responsiveness and inflammation
The effect of OVA and L. dentata extract on the content of Triglycerides and total Cholesterol in serum
The treatment with OVA caused a significant increase in content of Triglycerides and total Cholesterol in serum when compared with control group (Table 2)
Summary
Asthma is a chronic disease defined by variable features, including reversible airways obstruction, airway responsiveness and inflammation. In 2014, it affected around 300 million people worldwide (GINA, 2014). The risk of developing asthma is enhanced by exposure to inhaled pollutants such as allergens, viruses, bacteria, fungi, tobacco smoke and. 1 pp. ozone, which initiate allergic symptoms (Holgate 2008; Selgrade et al, 2013). Oxidative stress plays a critical role in asthma pathogenesis. Several reports have demonstrated that oxidative stress is a crucial consequence of asthma inflammatory response (Nadeem et al, 2008; Wood et al, 2003).
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