Effect of laser acupuncture on disuse osteoarthritis: an ultrasound biomicroscopic study of patellar articular cartilage in rats.

Qing Wang,Yong-Ping Zheng,Xiao-Yun Wang,Xia Guo,Mu-Qing Liu

doi:10.1155/2012/838420

Abstract

To investigate the effect of laser acupuncture (LA) on disuse changes in articular cartilage using ultrasound biomicroscopy (UBM), Eighteen rats were randomly divided into the control group (C), the tail-suspended group (T), and the tail-suspended with LA treatment group (L). During 28-day suspension period, group L were treated with LA at acupoints on the left hindlimb while group T had a sham treatment. Ultrasound roughness index (URI), integrated reflection coefficient (IRC), integrated backscatter coefficient (IBC), cartilage thickness, and ultrasonographic score (US) of articular cartilage at patella were measured by using an ultrasound biomicroscopy system (UBS). Compared with the group C, URI significantly (P < 0.01) increased by 60.9% in group T, increased by 38.1% in group L. In addition, unloading induced a significant cartilage thinning (P < 0.05) in group T, whereas cartilage thickness in group L was 140.22 ± 19.61 μm reaching the level of the control group (147.00 ± 23.99 μm). There was no significant difference in IRC, IBC, and US among the three groups. LA therapy could help to retain the quality of articular cartilage which was subjected to unloading. LA would be a simple and safe nonpharmacological countermeasure for unloading-induced osteoarthritis. The UBM system has potential to be a sensitive, specific tool for quantitative assessment of articular cartilage.

Highlights

Articular cartilage use can be distinguished in to 3 different patterns that have different consequences: normal use, marked decrease use, and use that damages the tissue
Our previous study found that 28-day unloading affected articular cartilage site-dependently in ultrasound parameters [17]
The therapeutic effects of laser acupuncture (LA) on patellar articular cartilage subjected to unloading were assessed by using a high-frequency ultrasound biomicroscopy (UBM) system

Summary

Introduction

Articular cartilage use can be distinguished in to 3 different patterns that have different consequences: normal use, marked decrease use (disuse), and use that damages the tissue (abuse). It has been found that the absence of joint loading associates with markedly increased percentage of apoptotic chondrocytes [2], decrease of matrix synthesis and content production and cartilage thinning [3,4,5]. These site-specific changes of articular cartilage could be a reversible tentative phenomenon or progress to osteoarthritis (OA), depending on the magnitude and type of altered loading [6]. LA has been shown as an effective countermeasure for unloading-induced bone loss [11] It is unknown whether it can subside cartilage degeneration caused by unloading

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