Abstract
Aims: This study aimed to determine the role of L - arginine on eNOS expression and its role on the level of some antioxidants as reduced glutathione and catalase in alloxan - induced diabetic rats. Study Design : Ninety adult male albino rats were divided into three (3) groups of thirty rats (30) each: Group (I): Control group, Group (II ) : Diabetic control group, Group (III): L - arginine treatment group. The secon d and the third group s were made diabetic by intraperitoneal administration of 80 mg/kg alloxan monohydrate , while L - arginine (100 mg/kg in sterile 0.9% Nacl) was given orally to rats in group III for one week before alloxan injection, and a further four weeks after induction of diabetes. The animal s were sacrificed and blood collected for the determination of biochemical and antioxidant ma rkers. Heart tissues were homogenized for determination of expression of eNOS gene by RT - PCR. Results: The study showed that L - arginine increases HDL, reduces glu tathione and catalase and decreases LDL, TAG, Cholesterol and MDA. It also increased the expression of eNOS in heart tissues of diabetic rats.
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