Effect of large dose of Methylprednisolone on epilespy combined with electrical status epilepticus during sleep in children

Abstract

Objective To investigate the clinical effect of large dosage of Methylprednisolone on epilespy combined with electrical status epilepticus during sleep(ESES) in children. Methods Forty-six epielpsy patients with ESES were treated with additive large dosage of Methylprednisolone.The seizures and video electroencephalogram discharges were observed before and after using Methylprednisolone.The Methylprednisolone effect in eliminating the methylprednisolone of ESES and controlling of clinical seizures and improving cognitive function were analyzed. Results Two cases were lost and 44 cases were included, male 30, female 14, the age at onset was (5.37±2.52)(2-9) years old.The duration of follow-up was (4.12±2.00)(1-9) years old.The age at diagnosis of ESES was (8.17±2.09)(4.0-12.5) years old.The efficacy of Methylprednisolone on seizures was 72.7%(32/44 cases), while the efficacy of Methyl prednisolone on electroencephalograph(EEG) was 59.1%(26/44 cases). For patients who were resistant to Levetiracetam or Clonazepam, Methylprednisolone was still effective.Intelligence quotient had no significant changes before and after treatment(P>0.05). The earlier onset age, the worse effect of Methylprednisolone.The efficacy of methylprednisolone for atypical benign epilepsy with cento-temporal spike(BECT) was higher than other syndromes. Conclusions Large dosage of Methyl prednisolone therapy for children with ESES, especially for those resistant to traditional or new antiepileptic drug for ESES, was effective and safe.The onset age and syndrome classification may have a certain value for prognosis and prediction of the effect of Methylprednisolone treatment. Key words: Epilepsy; Electrical status epilepticus during sleep; Methylprednisolone; Spike wave index