Effect of Laparoscopic CME In Patients With Right Colon Cancer and Its Effect On VEGF, CCSA-2 and sICAM-1

Abstract

Objective To investigate the effect of laparoscopic CME in patients with right colon cancer and its effect on vascular endothelial growth factor(VEGF), colon cancer-specific antigen-2(CCSA-2) and soluble intercellular adhesion molecule-1(sICAM-1). Methods A retrospective analysis of 82 patients with right colon cancer who were treated in our hospital from March 2012 to October 2014 were retrospectively analyzed. According to the different surgical methods, 41 cases were divided into laparotomy group and 41 cases were divided into laparoscopic group. SPSS 19.0 was used to analyze the results. Surgical data and tumor markers were expressed as (±s), and compared with independent t-test, the recurrence rate and mortality within 3 years were compared with χ2 test. The difference was statistically significant at P<0.05. Results The amount of bleeding, the time of anus exhaust, the amount of postoperative drainage volume and the days of hospitalization in the laparoscopic group were all lower than those in the laparotomy group (P 0.05). The levels of VEGF, CCSA-2 and sICAM-1 in the two groups were significantly increased at the third day after operation, and the levels of these indexes in the laparoscopic group were significantly lower than those in the laparotomy group (P<0.05). The total incidence of postoperative complications of the laparoscopic group(12.2%) was lower than that of the laparotomy group(46.3%) (P<0.05). The disease recurrence rate (9.8%) and mortality rate (4.9%) within postoperative 3-years of laparoscopic group were lower than the laparotomy group (31.7% and 24.4% respectively) (P<0.05). Conclusion The clinical effect of laparoscopic CME on right colon cancer patients is good, which can effectively reduce the levels of VEGF, CCSA-2 and sICAM-1 in patients with less postoperative complications, its short-term curative effect is better, and its disease recurrence rate and mortality within postoperative 3-years are lower, which can achieve better long-term prognosis. Key words: Colonic neoplasms; Laparoscopy; Tumor markers, biological; Treatment outcome; Recurrence