Abstract
Aim:To study the effect of lanosterol on age-related cataractous human lens nuclei.Materials and Methods:Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity.Results:Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days.Conclusion:Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.
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