Effect of Lagenaria siceraria and Trigonella foenum graecum on Lipid Absorption and Excretion for Modulation of Lipid Profile

Abstract

Background: Hyperlipidemia is a metabolic disorder characterized by elevated serum total cholesterol, low density and decreased high-density lipoprotein levels. Lagenaria siceraria contains saponins and dietary fibers which are helpful in faster removal of fatty acids and in promotion of bile acid formation. Similarly Trigonella foenum graecum contains steroidal saponins and soluble fibers which have been attributed to anti-hyperlipidemic activity. Objective: The objective of the study was to evaluate anti-hyperlipidemic activity of the combinatorial extract of Lagenaria siceraria and Trigonella foenum graecum. Materials and Methods: In the present study, hyperlipidemia was induced in rats by a single dose of Triton WR-1339 (300 mg kgG). The treatment group comprised of ethanolic extracts of Lagenaria siceraria fruit (200 mg kgG), Trigonella foenum graecum extract (200 mg kgG), combinatorial extract (100 and 100 mg kgG) and Atorvastatin (10 mg kgG). Activity was confirmed by biochemical analysis of blood plasma. Results: It was observed that there was a significant decrease (p<0.001) in triglyceride, total cholesterol and LDL plasma concentration and an increase in plasma HDL levels. The combinatorial extract effectively modulated the lipid profile in hyperlipidemia induced rats. Conclusion: The combinatorial extract of Lagenaria siceraria fruit and Trigonella foenum graecum can potentially serve as therapeutic agents in the treatment of coronary artery diseases.