Effect of Lactobacillus plantarum on Intestinal Infection in Multiple Drug-Resistant Bacteria Mice

Abstract

This study aimed to determine the effects of probiotic Lactobacillus plantarum on colitis in mice with multiple drug-resistant bacteria, and to judge the intervention function of probiotics in the resistance of pathogenic bacteria. Male BALB/C mice were divided into four groups. The colonic tissues were collected for pathology observation, permeability, transepithelial electrical resistance (TER), and tight junction protein expression detection at death, and the feces were collected for detecting drug susceptibility of MDR-PA. MDR-PA mice developed severe intestinal inflammation and tissue damage in which paracellular permeability was increased, in conjunction with decreased expression and redistribution. LP administration attenuated colitis of MDR-PA mice. The drug susceptibility diameter of MDR-PA has increased. Probiotics can treat diarrhea of mice by MDR-PA and protect the intestinal barrier function. Probiotics can weaken the resistance of multiple drug resistance in Pseudomonas aeruginosa to some extent.