Abstract
The effects of two kefir strains, Lactobacillus mali APS1 (APS1) and L. kefiranofaciens M1 (M1), on energy and glucose homeostasis in diet-induced obese mice were investigated. Unexpectedly, these two strains exhibited completely opposite results. The high-fat diet (HFD) mice orally administered with APS1 had significantly reduced body weight gain, body fat, liver weight, and fat accumulation in the mesenteric adipose depot compared with HFD counterparts not receiving APS1. Dietary supplementation with APS1 also effectively maintained the blood glucose level. Conversely, M1-treated mice showed 23% higher body weight gain and 2.1-fold higher body fat than their HFD counterparts. Pyrosequencing analysis indicated that the selective modulation of gut microbiota by dietary treatment with two kefir strains may interact to affect insulin sensitivity, GLP-1 production, barrier integrity, and lipid metabolism. Regulation of inflammatory cytokines by the strains M1 and APS1 also played a key role in metabolic parameters of obesity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
