Abstract
Purpose: The aims of this study were to prepare a 0.1% Miconazole (MCZ) eye-drop solution and to evaluate the stability and physical properties of the preparation.
Highlights
The immune system performs a biological defense function in humans and protects the body from pathogenic microorganisms such as viruses and bacteria
Quantitation of MCZ using high-performance liquid chromatography (HPLC): Table 1 shows the results of MCZ content analysis under storage conditions of 4°C, 40°C, and 25°C (Figure 2)
The stability of the lactic acid-added system, in which the eye-drop solution was diluted with lactic acid and physiological saline, and that of the lactate Ringer’s Solution (LRS)-added system were evaluated
Summary
The immune system performs a biological defense function in humans and protects the body from pathogenic microorganisms such as viruses and bacteria. A weakened immune system increases the likelihood of fungal corneal infection or fungal intraocular (uvea) infection [1,2]. Fungal keratitisis among the most refractory to treatment and can cause corneal blindness [5]. Because fungal spores can cause damage to the cornea, healing takes time even if antifungal drugs are used. Antifungal drugs such as Miconazole (MCZ) and amphotericin B are prescribed in the form of eye-drops to prevent eye infections [6,7]. Few antifungal eye drops, including MCZ, are not commercially available and are currently being prepared as in-hospital formulations as needed [9]
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