Abstract
Gastric cannulae were placed in the stomach of four dogs. The acid output per hour was determined after (1) the subcutaneous injection of 0.1 mg histamine (base), (2) the subcutaneous injection of 1.0 mg histamine (base), and (3) the intravenous injection of 1.0 unit/kg of insulin. The pepsin concentration was also determined after the intravenous injection of 1.0 unit/kg of insulin. Following bilateral labyrinthectomy the gastric secretory studies were repeated at intervals. There was a depression of the acid output and the pepsin concentration in all dogs, to all the gastric stimuli, over a four-month period.
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