Abstract
l-Threonine produced significant reductions ( p < 0.001) in the incidence of trypan blue-induced exencephaly and the number of fetuses that were born with their eyes open when it was administered as a dietary supplement in gestating Swiss ICR:Ha albino mice. l-Phenylalanine exhibited a significant degree of protection against trypan blue-induced embryolethality. l-Leucine, l-lysine, l-tyrosine, l-histidine, and l-tryptophan did not exhibit any significant inhibition of trypan blue-induced embryolethality and gross malformations at the dosages that were employed in this study. The results obtained in this study suggest that antiteratogenic activity previously observed with desiccated bovine serum albumin and a casein-derived hydrolysate may have been due in part to the threonine content per se or the result of the synthesis of one or more intermediary metabolites of threonine.
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