Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats

Fernanda Bm Priviero,Alexandre S Silva,Angelina Zanesco,Julio A Rojas-Moscoso,Edson Antunes

doi:10.1186/1471-2210-9-s1-p54

Fernanda Bm Priviero, Alexandre S Silva + Show 3 more

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https://doi.org/10.1186/1471-2210-9-s1-p54

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Abstract

Background It has been largely documented the beneficial effects of physical training on the endothelium-derived relaxing response by increasing nitric oxide production and/or its bioavailability to the smooth muscle [1]. L-carnitine (LCar) has been used as important supplement to regulate body composition associated with lipid metabolism. However, no studies exist investigating the effect of L-Car intake associated with dynamic exercise on the NO-independent sGC/cGMP pathway in the vascular responsiveness in rats. Thus, the aim of this work was to investigate the effect of L-Car supplementation on the NO-independent sGC/cGMP pathway in aortic and mesenteric rings in trained rats.

Highlights

It has been largely documented the beneficial effects of physical training on the endothelium-derived relaxing response by increasing nitric oxide production and/or its bioavailability to the smooth muscle [1]
Oral supplementation with L-Car associated with run training provoked a significant reduction in body weight gain (368 ± 13 g) as compared to sedentary groups (SD: ± 9 and sedentary supplemented (SDS): ± 15 g)
The potency for sodium nitroprusside (SNP) was increased in trained supplemented (TRS) group as compared to sedentary groups

Summary

Introduction

It has been largely documented the beneficial effects of physical training on the endothelium-derived relaxing response by increasing nitric oxide production and/or its bioavailability to the smooth muscle [1]. L-carnitine (LCar) has been used as important supplement to regulate body composition associated with lipid metabolism. No studies exist investigating the effect of L-Car intake associated with dynamic exercise on the NO-independent sGC/cGMP pathway in the vascular responsiveness in rats. The aim of this work was to investigate the effect of L-Car supplementation on the NO-independent sGC/cGMP pathway in aortic and mesenteric rings in trained rats

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Conclusion