Effect of L-Arginine (L-arg) analogues on renal vascular resistance (RVR) in the neonatal rabbit kidney 1687

Abstract

Neonatal renal hemodynamics are characterized by a specific pattern of reactivity to various mediators, including nitric oxide (NO). Knowlegde on the role of NO in renal hemodynamics often relies on the interpretation of the effects of NO-synthase (NOS) inhibitors and/or NOS substrates L-arg analogues on renal vascular function. The aim of this study was to characterize the effects on neonatal renal hemodynamics in the rabbit of NG-nitro L-arginine methyl ester (L-NAME) and NG-monomethyl-L-arginine (L-NMMA), as NOS inhibitors, and of L-arg and benzoyl-arginine ethylester (BAEE), as NOS substrates.