Effect of L. acidophilus\xa0and B.\xa0lactis on blood glucose in women with gestational diabetes mellitus: a randomized placebo-controlled trial

Farnaz Sahhaf Ebrahimi,Aydin Tabrizi,Leila Khalili,Fatemeh Abbasalizadeh,Aziz Homayouni Rad,Metanat Mosen

doi:10.1186/s13098-019-0471-5

Farnaz Sahhaf Ebrahimi, Aydin Tabrizi + Show 4 more

Open Access

https://doi.org/10.1186/s13098-019-0471-5

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Abstract

BackgroundGestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Recently, probiotic use has been proposed for better control of glucose in GDM patients. The aim of this study was to evaluate the effect of probiotic yoghurt compare with ordinary yoghurt on GDM women.MethodsIn this double-blind placebo-controlled clinical trial, 84 pregnant women with GDM were randomly assigned into two groups of 42 recipients who underwent 300 g/day of probiotic yoghurt or placebo for 8 weeks. Blood glucose, HbA1c, and the outcome of pregnancy were compared between the two groups after the intervention.ResultsAccording to the findings of present trial no significant differences were observed in general characteristics between the two groups (p > 0.05). Both fasting and post prandial blood glucose as well as the level of HbA1c were decreased significantly in probiotic group (p < 0.05), although these changes are not statistically significant in the placebo group. The between group differences was significant after the 2 month intervention (p < 0.05). Neonates born of probiotic group mothers, have significantly lower weight and fewer macrosome neonates were born in this group compared with control group (p < 0.05). However, no difference was observed in other values of outcome.ConclusionsOur study revealed that better control of blood glucose can be achieved by consumption of probiotic yoghurt in patients whose pregnancy is complicated by GDM, compared with placebo. Also incidence of macrosomia may be decreased by this regimen.

Highlights

Gestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes
Plain English summary Present trial conducted to evaluate the effect of probiotic yoghurt containing L. acidophilus and B. lactis compare with ordinary yoghurt containing S. thermophilus and L. bulgaricus on GDM women
The results of this study revealed that better control of blood glucose can be achieved by consumption of probiotic yoghurt in patients whose pregnancy is complicated by GDM, compared with placebo

Summary

Introduction

Gestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Some of the mostly documented health benefits for probiotics include effectiveness against diarrhea, improvement of lactose metabolism, immunomodulation, as well as anti-inflammatory, anti-carcinogenic, anti-diabetic, hypo-cholesterolemic, and hypotensive characteristics [6, 9,10,11]. In addition to their impact on gastrointestinal disorders, the effect of probiotics on the improvement of blood glucose and lipid profile in patients with type 2 diabetes mellitus and GDM has been reported [12,13,14,15]. Considering the potential of probiotic bacteria, the aim of the present trial was to investigate the effects of probiotic yoghurt containing L. acidophilus and B. lactis consumption on the glycemic parameters including FBG, post prandial BS, and HbA1c and the outcome of pregnancy including gestational age, weight, length, head circumference, macrosomia, and admission to NICU in GDM patients

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