Abstract
According to the most predominant hypothesis, Parkinsonism, the main symptoms of which are tremor, muscle rigidity and akinesia, seems to result from disturbances in the basal ganglia, especially disturbance of the amine balance between the cholinergic and dopaminergic system in the corpus striatum (1, 2). L-Dopa (L-dihydroxyphenylalanine) has recently been used, as well as anticholinergic agents, antihistamines and phenothiazines. in the treatment of Parkinsonism. Although it is remarkably effective against muscle rigidity and akinesia, L-dopa shows only slight inhibition against tremor both in animal experiments and clinical cases (3). Some authors ascribe Parkinsonism to a decrease in intracerebral 5-HT (5-hydroxytryptamine) level (4) and there are reports about the application of 5-HTP (5-hydroxytryptophan), a metabolic precursor of 5-HT, to the treatment of Parkinsonism (5, 6).
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