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Abstract
Objective: To observe the effect of Kidney tonic, the Migu Tablet ( ) on bone and endocrine of osteoporosis rats.Methods: Two stages were divided, stage 1: Using ovariectomy to establish the osteoporosis rat model; stage 2: Treating the model;Results: After 3 months treatment with MGT, which can prevent the lowering of femur bone density, tibia trabecular volume and femur bending resistant strength, but was unable to raise those lowered parameters. Serum corticosterone determination showed that the Kidney tonic could regulate the secretion of estrogen and testosterone, adjust the imbalance of E2/T ratio.Conclusions: MGT, a Kidney tonic could prevent and treat experimental osteoporosis, its imbalance of E2/T ratio adjustment is possibly one of the mechanisms to lessen the patient’s Kidney deficiency.
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