Effect of Ketogenic Diet on the Progression of 7, 12-Dimethylbenz(Α) Anthracene –Induced Mammary Cancer in Female Wistar Rats

Abstract

In the present research, the level of cancer antigen 125 (CA125) significantly increased in DMBA experimental groups (group II) compared to normal control group. However the level of CA125 decreased in dose dependent manner with 10% carbohydrate ketogenic diet having the most significant effect. Also, the 7,12-Dimethylbenz(α) anthracene (DMBA) caused significant increase in liver enzymes (Alanine amino transferase, Aspartate amino transferase and Bilirubin) of 41±1.06, 40±1.16, 20.80 ±1.47 and 25±1.34, 27±143, 12.17±1.08 compared to normal control at P<0.05 respectively. Furthermore, with the group treatment 10%, 20% and 30% carbohydrate ketogenic diets also elevated the liver enzymes. More so, a significant decrease was observed in total protein, albumin, RBC, Hb, PCV, MCH superoxide dismutase, glutathione reductase and glutathione peroxidase with a corresponding increase in white blood cells. Interestingly, ketogenic diets significantly increase total protein, albumin, superoxide dismutase, glutathione reductase, and glutathione peroxidase with a decrease in white blood cells, total cholesterol, triglyceride, low density lipoprotein bilirubin concentration. It can therefore be concluded that, the administration of ketogenic diets slows the progression of breast cancer through inhibiting the downstream of insulin receptors of both mammalian target of rapamycin signal cascade and motogen activator protein kinase pathways.