Abstract
Effect of Ketoconazole on Early Maternal Separation Stress Model in Rats: A Neurobehavioral and Biochemical Approach
Highlights
Social ties, principally mother-infant relationship during the infantile period, have a critical role in the development of the brain and behavior in adulthood (Amiri et al, 2016)
Hematological Study Our data (Table 1) showed that maternal separation cause a significant increase in withe blood cells and monocyte counts, and a significant decrease in neutrophils, lymphocyte, and eosinophils counts as compared to control group
The hematological parameters results in maternal separation treated group were similar to the control group
Summary
Principally mother-infant relationship during the infantile period, have a critical role in the development of the brain and behavior in adulthood (Amiri et al, 2016). It is shown that neonate exposure into psychosocial adversities, like maternal separation (MS) stress, dramatically interrupt brain development and augments the risk of neuropsychiatric diseases including anxiety and depression (Haj-Mirzaian et al, 2017). It includes permanent farewell and short-term separation or repetitive separation during the process of early childhood development. Clinical studies suggest that adults with the experience of childhood parental loss are vulnerable to stress and have a greater risk of suffering psychiatric disorders such as depression and anxiety (Longstaffe, 1979; Harris et al, 1986; Agid et al, 1999).
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