Effect of Kepok Banana Peel Extract (Musa Paradisca L.) on Leading Time in Balb-C Strain Mice

Abstract

The prevalence of bleeding complications after tooth extraction reached 31.5%. Hemostasis process is needed in this situation to avoid complications after tooth extraction. Kepok banana peel (Musa paradisiaca L.) is one of the traditional plants that can help the hemostatic process. Therefore, the purpose of this study was to determine the effect of giving kepok banana peel extract (Musa Paradisiaca L.) on bleeding time in cutting the tails of male mice, with the hope that in the future it can be used as an alternative for bleeding therapy after tooth extraction. Observations were made by taking 12 mice as samples and divided into three groups, namely the negative control group (K-), the positive control group (K+), and the treatment group (P). In the K- group, the mice were subjected to aquadest solution of 0.4 ml/20 mg BW, in the K+ group, tranexamic acid was probed at a dose of 0.065 mg/g BW mice as much as 0.4 ml/20 mg BW mice , and in the P group the kepok banana peel extract was probed with a dose of 1.55 mg/g BW mice as much as 0.4 ml/20 mg BW mice orally. All groups were cut on the tails of mice with a length of 0.5 cm. The cut wounds on the tails of mice were dripped onto absorbent paper boxes which were divided into 16 boxes, with an interval of 30 seconds in each box. The results showed that the administration of kepok banana peel extract (Musa Paradisiaca L.) had the effect of accelerating bleeding time on tail cutting of mice with BalB-C strain.