Abstract
Background:Kangfuxin Liquid is extracted from America periplaneta, which is effective for treating gastrointestinal ulcers and repairing gastrointestinal mucosal tissue. The purpose of this study is to explore the effect of Kangfuxin Liquid on improving intestinal barrier dysfunction in elderly patients using mechanical ventilation and effectively restraining the concentration of D-lactate.
 Materials and Methods: Elderly patients with mechanical ventilation were selected, and divided into “control” and “treatment” groups by using a random number table. Patients in both groups were given conventional treatment. Patients in “treatment group” additionally received Kangfuxin Liquid. At baseline and at 3, 7days following treatment, recordings for the concentration of D-lactate, intra-abdominal pressure (IAP) and bowel sounds were conducted. The duration of mechanical ventilation, the time of stay in ICU and the mortality rate during 28 days were recorded. 
 Results: At baseline, there were no significant differences in the terms of the concentrations of D-lactate, IAP and bowel sounds in the two groups (P>0.05). At 3 and 7days following treatment, the concentration of D-lactate, IAP and bowel sounds in the “treatment group” were better than those in the “control group”. The differences were statistically significant (P
Highlights
During recent years, elderly patients with mechanical ventilation are gradually rising as a result of population demographics
Background:Kangfuxin Liquid is extracted from America periplaneta, which is effective for treating gastrointestinal ulcers and repairing gastrointestinal mucosal tissue
The purpose of this study is to explore the effect of Kangfuxin Liquid on improving intestinal barrier dysfunction in elderly patients using mechanical ventilation and effectively restraining the concentration of D-lactate
Summary
Elderly patients with mechanical ventilation are gradually rising as a result of population demographics. Kangfuxin Liquid is used to improve the intestinal barrier dysfunction in elderly patients, and explore the effect on restraining the concentration of D-lactate. Kangfuxin Liquid is extracted from America periplaneta, which is effective for treating gastrointestinal ulcers and repairing gastrointestinal mucosal tissue. The purpose of this study is to explore the effect of Kangfuxin Liquid on improving intestinal barrier dysfunction in elderly patients using mechanical ventilation and effectively restraining the concentration of D-lactate. Results: At baseline, there were no significant differences in the terms of the concentrations of D-lactate, IAP and bowel sounds in the two groups (P>0.05). Conclusion: Kangfuxin Liquid can restrain the concentration of D-lactate, improves intestinal mucosal permeability, enhances the intestinal barrier, and improves the condition in elderly patients with mechanical ventilation
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