Abstract
Kaempferol is a polyphenolic compound and are widely distributed in plants. It is used in the treatment of different disease conditions. With the endemic resistant parasites against most antitrypanosomal agents and the toxicity associated with diminazene aceturate, the search for safer and more effective alternative therapy of trypanosomosis becomes paramount. In this study the effect of treatment with kaempferol and diminazene aceturate on Hematological parameters in mice with experimental Trypanosoma brucei brucei infection was evaluated. Thirty six adult swiss albino mice of either sex were randomly divided into six groups of six mice each. Mice in group I were untreated uninfected. Mice in group II were pre-treated with kaempferol (1 mg/kg) for 14 days. Mice in groups II to VI each were inoculated with blood containing Trypanosoma brucei brucei (106 trypanosomes/ml of blood/animal) intraperitoneally. Following establishment of the infection (four days post-inoculation), mice in group III were treated once with diminazene aceturate (3.5 mg/kg) I.P. Mice in group IV were treated with diminazene aceturate (3.5 mg/kg) once I.P, and then continued with kaempferol (1 mg/kg) for nine days.
Highlights
In Africa, trypanosomosis is one of the neglected parasitic diseases of animal and human, which accounts for the low livestock productivity (Welburn et al, 2006)
The pathogenesis of African trypanosomosis is partly due to the generation of reactive oxygen species (ROS) due to stress induced by the parasite, which causes degenerative changes in cells, tissues and organs of the infected animals (Kobo et al, 2014).The ROS attack both the membrane polyunsaturated fatty acids and proteins of RBCs, leading to oxidative hemolysis and anemia as well as the depletion of endogenous antioxidant reserved in the blood and other tissues of trypanosome-infected animals (Kobo et al, 2014)
There was significant (P < 0.001) decrease in the level of Parasitaemia in mice treated with kaempferol only when compared to mice pretreated with kaempferol and those that were administered normal saline, this agrees with the findings of Kobo et al (2014) which showed delayed proliferation of Trypanosoma brucei brucei in rats treated with mixtures of flavonoids, the effect was attributed to scavenging ability of the flavonoids on free radicals generated during the course of infection
Summary
In Africa, trypanosomosis is one of the neglected parasitic diseases of animal and human, which accounts for the low livestock productivity (Welburn et al, 2006). The pathogenesis of African trypanosomosis is partly due to the generation of reactive oxygen species (ROS) due to stress induced by the parasite, which causes degenerative changes in cells, tissues and organs of the infected animals (Kobo et al, 2014).The ROS attack both the membrane polyunsaturated fatty acids and proteins of RBCs, leading to oxidative hemolysis and anemia as well as the depletion of endogenous antioxidant reserved in the blood and other tissues of trypanosome-infected animals (Kobo et al, 2014). The effects of treatment with kaempferol and/or
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
