Abstract
Primary dysmenorrhea is a common gynecological disease garnering increasing attention and research. To investigate the clinical therapeutic effects of Jingqian Zhitong Fang (JQF) and the differences in serum sex hormone levels during the treatment of primary dysmenorrhea, we selected 30 healthy volunteers and 60 individuals with primary dysmenorrhea. On the third day of the menstrual cycle, we used ELISA to determine the levels of serum prolactin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TEST), progesterone (PROG), and estradiol (E2) compared with normal levels and levels in the JQF group, the Western medicine group receiving continuous treatment during the first and third menstrual cycles, and the group followed up after the drug was stopped. We observed that after JQF treatment, the levels of the following hormones changed significantly: PRL, LH, TEST, and E2 levels decreased significantly and the PROG level increased significantly after treatment. After treatment with Western medicine, the serum levels of FSH, LH, PROG, and E2 showed no significant change. We conclude that the long-term effect of JQF treatment was better than that of Western medicine. JQF treatment of primary dysmenorrhea is related to adjustment of PRL, LH, TEST, and E2 hormone levels in the human body.
Highlights
Primary dysmenorrhea (PD) is characterized by cramping pelvic pain at the onset of menses, lasting for 48–72 hours during the menstrual cycle, and is highly prevalent among adolescent girls [1, 2]
Venous blood was collected on the third day of the menstrual cycle, and the six serum sex hormone levels were measured
The results showed that the PRL, TEST, and E2 levels were higher in the dysmenorrhea group than in the healthy groups (P < 0.01)
Summary
Primary dysmenorrhea (PD) is characterized by cramping pelvic pain at the onset of menses, lasting for 48–72 hours during the menstrual cycle, and is highly prevalent (approximately 50%) among adolescent girls [1, 2]. Prostaglandins are smooth muscle stimulants [5]. Powell et al found that the levels of menstrual PGF2α and PGE2 were significantly higher in women with dysmenorrhea than in healthy women [6]. High progesterone levels can decrease the incidence of breast cancer. They can cause tumor formation [8]. Some studies have reported that primary dysmenorrhea may be caused by endometriosis, which can aggravate dysmenorrhea [10]. Patients with both adenomyosis and endometriosis show high levels of E2, FSH, and LH [7]. It is necessary to study the relationship between the occurrence of dysmenorrhea and the disequilibrium of sex hormones
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
