EFFECT OF ISOTRETINOIN ORAL ON ACNE VULGARIS (A REVIEW OF SYSTEMATIC AND METAANALYSIS STUDIES ON ALANINE AMINOTRANSFERASE LEVELS, ASPARTATE AMINOTRANSFERASE, LIPID PROFILE, HOMEOSTATIC MODEL ASSESSMENT FOR INSULIN RESISTANCE, COMPLETE BLOOD COUNT, FASTING BLOOD GLUCOSE)

Abstract

Background: Oral isotretinoin is known to has a large role in the treatment of acne vulgaris, but unfortunately has signicant side effects. Observation of laboratory changes during oral isotretinoin intake is important in order to ensure safety. Medline Pubmed, Scopus, Methods: ProQuest, Cochrane library, ClinicalTrials.gov, the reference list, conference proceedings, researchers in eld of eligible studies were searched. Result: 17 studies (1573 patients) were included into meta-analysis. Mean difference values (95% CI) increase for triglycerides 25,81 mg/dL, total cholesterol 16,11 mg/dl, Low-Density Lipoprotein cholesterol (LDL) 15,11 mg/dL, Aspartate Aminotransferase (AST) 3,08 U/L, Alanine Aminotransferase (ALT) 1.61 U/L, hemoglobin 0,18 g/dl, fasting glucose 0,55mg/dL. High-Density Lipoprotein cholesterol (HDL) decrease 3,09 3 3 mg/dl, White Blood Cell (WBC) decrease 0.23 x10 /μL, neutrophils decrease 0,26 x10 /μL. The qualitative analysis found that HOMA IR had increase in mean value. Longer laboratory evaluation time, can reduce the cost Conclusion: of treatment and discomfort of patients in acne therapy. Acne patient with abnormal baseline values of laboratory parameters should avoid taking oral isotretinoin