Effect of isoproterenol on induction of ventricular tachyarrhythmias in the normal and infarcted canine heart

Abstract

The influence of isoproterenol on induction of ventricular arrhythmias was evaluated in 10 normal dogs and 17 dogs with experimentally induced myocardial infarction. Programmed stimulation (using up to 6 extrastimuli) was performed before and then during infusion of isoproterenol (2 μg/minute followed by 4 μg/minute). Isoproterenol facilitated induction of sustained monomorphic ventricular tachycardia (cycle length 163 ± 26 msec) in 5 of the 10 animals with no inducible baseline arrhythmia ( P < 0.05). Isoproterenol did not affect cycle length or the number of extrastimuli required in animals with baseline ventricular tachycardia (cycle length 158 ± 15 msec before versus 163 ± 17 msec during isoproterenol, P = 0.3; extrastimuli 3.8 ± 0.6 before versus 3.8 ± 0.4 during isoproterenol infusion, P = 0.3). Isoproterenol did not significantly facilitate induction of ventricular fibrillation in either normal dogs or those studied after production of myocardial infarction. We conclude that infusion of isoproterenol increases the incidence of inducible ventricular tachycardia in the infarcted heart, but does not facilitate the induction of ventricular fibrillation in infarcted or normal hearts, despite the use of an aggressive protocol for programmed stimulation. Isoproterenol is, therefore, a safe and useful adjunct to programmed stimulation in this setting.