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Abstract
To observe the transcriptional regulation of the two isoflavones genistein and daidzein on target genes. In this study, we used ERalpha or ERbeta over-expressing Hela cells to observe the transcriptional regulation of genistein and daidzein on ERE reporter gene with calcium-phosphate method, and furthermore observing the effects of phytoestrogen antagonist ICI 182780 on their activation. Our results showed that both genistein and daidzein could activate ERE receptor gene through ERalpha and ERbeta, and these effects could be blocked by ICI 182780. Both genistein and daidzein can mimic estrogen's effect to activate the transcription of target genes through binding to the ERs.
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