Abstract
The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α- tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.
Highlights
Hypothyroidism is a clinical entity resulting from deficiency of thyroid hormones or, more rarely, from their impaired activity at the tissue level
The basal metabolic rate is decreased, as are other processes dependent upon thyroid hormones [1].Thyroid hormones are secreted by follicular cells in the thyroid gland
PTU exposed rats showed hypothyroidism which was evidenced biochemically by significant (P
Summary
Hypothyroidism is a clinical entity resulting from deficiency of thyroid hormones or, more rarely, from their impaired activity at the tissue level. Constitutes the most common endocrine abnormality in recent years, diagnosed either in subclinical or clinical form and is associated with various metabolic abnormalities, due to the effects of thyroid hormones on most major metabolic pathways [5], increasing the basal metabolic rate, affecting protein synthesis, regulating the metabolism of protein, lipids and carbohydrates [6] and involved in the regulation of oxidative metabolism [7]. They can cause many changes in the number and activity of mitochondrial respiratory chain components. Some studies have shown an increased production of International Journal of Nutrition and Food Sciences 2016; 5(3): 201-210
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