Abstract
Uptake of d-glucose, l-lysine and l-proline and the kinetic parameters of alkaline phosphatase and γ-glutamyl-transpeptidase were evaluated in renal brush border membrane (BBM) vesicles prepared from control, pyelonephritic and iron-administered pyelonephritic rats. The uptake of d-glucose and amino acids and Vmax of both the enzymes studied were found to be altered in pyelonephritic and iron-administered pyelonephritic rats, but changes appeared earlier and more severely in iron-administered infected animals than in other infected animals. These early physiological alterations were accompanied by higher bacterial colonisation in iron-administered rats.
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