Abstract
Wistar-strain female rats (about 40g b. w.) were fed a normal or an iron-deficient diet for 8 weeks, and 10% ethanol (v/v) was simultaneously given as drinking water for the last 4 weeks.The iron-deficient diet decreased Fe level and increased Cu level in all subcellular fractions of the liver. In addition, the iron-deficient diet decreased Zn level in microsomal and cytosolic fractions.The ingestion of ethanol under conditions of iron-adequacy resulted in a decrease of Cu, Zn and Se levels in the nuclear fraction, Mn level in nuclear and mitochondrial fractions, and Mg level in nuclear and cytosolic fractions.The ingestion of ethanol under iron-deficiency resulted in a decrease of Fe and Mn levels in the nuclear fraction, and an increase of Mn level in the microsomal and cytosolic fractions, and Mg and P levels in the microsomal fraction.These observations suggest that chronic alcohol ingestion could accelerate the biological effects of iron-deficiency anemia induced by Fe-deficient diet through the further decrease of Fe content in the nuclear fraction, and increase of Mn content in the cytosolic fraction.
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