Effect of iron chelating drug, Deferiprone and the water extract of green tea in the treatment of iron overload in local rabbits

Abstract

The current study was designed to study and compare the effect of the iron chelating action of the green tea (Camellia sinensis) Aqueous extract of green tea at a concentration of 100 mg / 1 kg and compared with the oral medicine , Deferiprone used to remove iron from the body. 25 mg / kg body weight . and the study of some of the biochemical variables associated with iron overload. Ferrous sulphate, (tablets200mg) was used to raise the proportion of iron in laboratory animals. . The laboratory animals (rabbits weighing 1 .to 1.5 kg) were given 10 mg / kg body weight,The treated groups were divided into four groups (five rabbits per group). The groups included the control group without treatment with any substance. The second group was treated with iron only and the third group was treated with iron with green tea. The fourth group was treated with iron with DeferiproneThe treatment of the four groups lasted for one month and then the animals were starved. The blood sample was withdrawn from the rabbits according to the usual laboratory methods. The study included determination of hepcidin, total iron binding capacity, ferritin, and serum iron ,Laboratory results showed significant increase (P ≤ 0.01) in the concentrations of hepecidin for the second group compared with control group and significant decrease (P ≤ 0.01) for the third group and the fourth group compared with the control groupAs for the ferritin, there was a significant increase (P ≤ 0.01) for the second and third groups, while the fourth group did not differ significantly compared to the control groupAs for TIBC, there was a significant increase (P ≤ 0.01) for the fourth group compared to the control group. A significant decrease was observed for the second and third groups compared with the control group at (P ≤ 0.01)Serum iron was found to have a low significant differences (P ≤ 0.01) for the second, third and fourth groups when compared to the control group.