Abstract
Radiation-induced impairment of hippocampal neurogenesis seems to play a central role in the pathogenesis of neurocognitive deficits after whole brain radiotherapy. Moreover, proinflammatory cytokines like IL-6 have been demonstrated to inhibit hippocampal neurogenesis. Here, we investigate at what radiation dose the hippocampal cytokine release and neurogenesis is affected, using a (transgenic) murine tissue slice model.
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