Abstract
The aim of the study was to investigate the effect of prebiotic fibres on appetite-regulating hormones, subjective feeling of appetite and energy intake in subjects with type 2 diabetes. Data presented are secondary outcomes of a study investigating the effect of prebiotics on glucagon-like peptide-1 and glycaemic regulation. We conducted a randomised and placebo-controlled crossover trial to evaluate the effects of 16 g/d of inulin-type fructans or a control supplement (maltodextrin) for 6 weeks in randomised order, with a 4-week washout period in-between, on appetite in thirty-five men and women with type 2 diabetes. Data were collected at visits before and after each treatment: plasma concentration of the satiety-related peptides ghrelin and peptide YY (PYY) were assessed during a standardised mixed meal. The subjective sensation of appetite was evaluated in response to an ad libitum lunch by rating the visual analogue scale. Twenty-nine individuals (twelve women) were included in the analyses. Compared to control treatment, the prebiotics did not affect ghrelin (P =0⋅71) or the ratings of hunger (P = 0⋅62), satiety (P = 0⋅56), fullness (P = 0⋅73) or prospective food consumption (P = 0⋅98). Energy intake also did not differ between the treatments. However, the response of PYY increased significantly after the control treatment with mean (sem) 11⋅1 (4⋅3) pg/ml when compared to the prebiotics -0⋅3 (4⋅3) pg/ml (P = 0⋅013). We observed no effect of inulin-type fructans on appetite hormones, subjective feeling of appetite or energy intake in patients with type 2 diabetes.
Highlights
Overweight and obesity represent a global epidemic, associated with comorbidities such as type 2 diabetes, unfavourable alterations of gut bacteria and low-grade inflammation[1]
The use of novel food ingredients has received increased attention in the prevention and treatment of overweight and its comorbidities. Among these are the non-digestible prebiotic fibres that are favoured and fermented by gut bacteria associated with improved health, of which inulin-type fructans (ITF) and Abbreviations: GLP-1: glucagon-like peptide-1; ITF: inulin-type fructans; PYY: peptide YY; VAS: visual analogue scale * Corresponding author: Eline Birkeland, email eline.birkeland@ous-hf.no journals.cambridge.org/jns
The data presented in this present paper are secondary outcomes of a study investigating the effect of prebiotics on glucagon-like peptide-1 (GLP-1) and glycaemic regulation
Summary
Overweight and obesity represent a global epidemic, associated with comorbidities such as type 2 diabetes, unfavourable alterations of gut bacteria and low-grade inflammation[1]. Regulation of appetite is complex and not yet fully understood. It involves communication between the gut and the brain with positive and negative autonomic and hormonal feedback signals[6]. The use of novel food ingredients has received increased attention in the prevention and treatment of overweight and its comorbidities. Among these are the non-digestible prebiotic fibres that are favoured and fermented by gut bacteria associated with improved health, of which inulin-type fructans (ITF) and journals.cambridge.org/jns
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