Abstract
Background This study aimed to evaluate treatment outcomes of culture-negative keratitis-induced endophthalmitis (CNKE). Methods We reviewed the medical records of 13 patients with CNKE, who underwent treatment from January 2011 to December 2017. All patients were referred from the emergency department or outpatient departments of local clinics. Outcome evaluation included the assessment of visual acuity and any need for evisceration/enucleation. Results Thirteen eyes of 13 patients were included in this study. The mean age of the patients was 75.0 ± 13.3 years. All patients had used antibiotic eye drops before the initial visit. Visual acuity values at the initial visit ranged from no light perception to 2/100; final visual acuity values ranged from no light perception to 2/100. All patients underwent a vitreous tap and intravitreal ceftazidime/vancomycin injection. Two eyes underwent evisceration after intravitreal injection. Conclusions Intravitreal antibiotic injections demonstrated favorable results for the treatment of patients with CNKE.
Highlights
This study aimed to evaluate treatment outcomes of culture-negative keratitis-induced endophthalmitis (CNKE)
Visual acuity values at the initial visit ranged from no light perception to 2/100, while final visual acuity values ranged from no light perception to 2/100
All patients were referred from local clinics, via the emergency room (ER) or outpatient department (OPD)
Summary
This study aimed to evaluate treatment outcomes of culture-negative keratitis-induced endophthalmitis (CNKE). Infectious endophthalmitis is a rare and vision-threatening ocular infection, involving the anterior and posterior chambers of the eye.[1] Endophthalmitis is classified into two categories: exogenous and endogenous, based on the route of infection. Exogenous endophthalmitis occurs when microbial pathogens enter the eye after intraocular surgery or trauma and spread from adjacent tissues or infiltrate through the corneal surface. Endogenous endophthalmitis is caused by the hematogenous spread of infectious organisms from an infection at a distant location into the eye. Microbial keratitis-associated endophthalmitis is uncommon, with a reported incidence of 6–10% of cases of exogenous endophthalmitis.[2] An earlier study revealed that 1.8% of patients with severe microbial keratitis required evisceration or enucleation, due to uncontrolled infection.[3]
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