EFFECT OF INTRAVESICAL CHEMOTHERAPY, MODIFIED BY ELECTROMAGNETIC FIELD IN THE SCANNING MODE, ON THE LEVEL OF ENDOTOXEMIA AND OXIDATIVE PROCESSES IN THE BLOOD IN PATIENTS WITH BLADDER CANCER

Abstract

Muscle-non-invasive bladder cancer (MNIBC) accounts of 70% of malignant lesions of this localization and has a high rate of recurrence and complications after treatment that requires improvement of the management of such patients. The developed modification of adjuvant intravesical chemotherapy (IVCT) necessitates the evaluation of endotoxemia and the adequacy of antioxidant protection of patients. The purpose of the study is the assessment of indices that reflect the functional state of albumin, the severity of endogenous intoxication (EI) and the state of free radical oxidation in the blood of MNIBC patients receiving adjuvant IVCT modified by the influence of scanning electromagnetic field. Material and methods. Endogenous intoxication indices, the light sum of peroxide induced luminol dependent chemiluminescence, malondialdehyde (MDA) content, activity of superoxide dismutase, catalase and glutathione system were investigated in the blood of MNIBC 30patients receiving chemotherapy under the impact of electromagnetic field during the process of dynamic monitoring of patients in comparison with a group of healthy persons. Results. Before treatment, MNIBC patients were characterized by the increased content of medium mass molecules (MMM) by 34-80% and decreased albumin binding capacity by 20%, that leading to an increase of EI coefficient by 81%, indicating to the presence of EI. The observed increase in the intensity, accumulation of molecular products of lipid peroxidation and the low level of activity of the main antioxidant enzymes indicated to the contribution of free radical processes in the metabolic state of these patients. After completion of adjuvant IVCT under simultaneous exposure to the local scanning electromagnetic field the decrease of main markers of endotoxemia - MMM254 and MMM280 was revealed. Full restoration of the albumin binding capacity and balanced operation of the antioxidant system was observed 9 months after the surgery. Conclusion. Biochemical data are consistent with the clinical efficacy of adjuvant IVCT combined with the scanning magnetic field, which allows to improve indices of 2-year disease-free survival to 94% and to double the latency period of relapse.