Abstract
The analysis of the behavioral effect of the nicotinic acetylcholine receptor (nAChR) antagonists has been generally based on drugs which act at the associated ion channel. In contrast dihydro-beta-erythroidine (DH,β E) is a competitive antagonist at the nAChR. Using rats, DH,β E was injected intraventricularly prior to training in two spatial tests, the Morns Water Maze and a Win-Stay radial maze. In addition DH,β E 300 nmol was used to reverse the effect of (−)-nicotine on locomotor activity. In the Moms Water Maze DH,β E (300 nmol) disrupted memory of the platform location as measured by crosses of the area in a probe trial. At 300 nmol DH,β E showed no sensorimotor effects in a visible platform test. In the Win-Stay task there was a significant, dose dependent disruption of spatial memory. A dissociation of nicotine's effects on locomotor activity was observed, in that DH,β E 300 nmol was able to significantly attenuate (−)-nicotine enhancement of horizontal motor activity, but did not affect the initial reduction of vertical activity. Nicotinic processing of memory appears to be involved in these tests of spatial memory.
Published Version
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