Abstract
Dose-dependent increases in free-field activity resulted from intraventricular infusions of dopamine and norepinephrine in unrestrained rats. Norepinephrine was more potent than dopamine in producing this hyperactivity. Pretreatment with imipramine, which blocks neuronal uptake of catecholamines, prevented the activation induced by infused dopamine without affecting the response to norepinephrine. However, the effects of dopamine and norepinephrine infusions were not differentially altered by haloperidol, an alleged dopamine receptor blocker. These results suggested that the activity produced by dopamine was due to its conversion to or displacement of norepinephrine and consequent excitation of noradrenergic receptors.
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