Abstract
After isolation and separation on columns of Sephadex G10, 5-hydroxyindole-acetic acid, homovanillic acid and 3-methoxy-4-hydroxyphenylglycol from human lumbar cerebrospinal fluid was measured fluorimetrically. Details about fluorimetry of the glycol are given. The effect of intravenously administered probenecid on the levels of the three compounds in lumbar CSF was investigated as a function of time. The acids, 5-hydroxyindoleacetic acid and homovanillic acid, accumulated not earlier than 6 hr after the administration of the drug. The noradrenaline metabolite, 3-methoxy-4-hydroxy-phenylglycol, did not accumulate under the influence of probenecid. The lag phase of about 4 hr before accumulation of the acids in lumbar CSF occurs, might reflect on the transport time along the spinal cord of the acids from the cisteraal- to the lumbar region.
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