Abstract
During the last 10 years, the use of intravenous nitroglycerin has become widespread in the therapy of patients with acute myocardial infarction [1–4]. The usual clinical indications for the use of this agent in patients with acute myocardial infarction are either early postinfarction angina or left ventricular failure. The goals of therapy are to prevent further episodes of myocardial ischemia and to improve left ventricular function by decreasing ventricular load. The prolonged use of cutaneous or intravenous nitroglycerin is limited by the rapid development of tolerance [5–8]. We have compared the acute and sustained (24-h) hemodynamic effect of intravenous isosorbide dinitrate with that of intravenous nitroglycerin in patients with acute myocardial infarction and elevated pulmonary artery wedge pressure.
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