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Abstract
The i.v. administration of Corynebacterium parvum (CP) to patients who had recently undergone resection of colorectal tumours was found to have the following effects: 1. Polymorphonuclear leucocyte counts were raised 24 h after CP administration, while both lymphocyte and monocyte counts fell during this period. Polymorph and lymphocyte counts had returned to pre-infusion levels at one week, but monocyte counts were significantly increased at this time. 2. The lymphocyte mitotic response to PHA was reduced during the 24 h after CP infusion. 3 The spontaneous, antibody-induced, and PHA-induced lymphocyte-mediated cytotoxicity against a nucleated target cell fell significantly 3 h after CP infusion, but these functions recovered by 7 days. 4. A rise in serum lysozyme was found 3 and 24 h after CP administration. However, these increased levels were not maintained beyond 24 h.
Highlights
In view of the suppression of lymphocyte function by Corynebacterium parvunt (CP) which has been reported in animal systems (Scott, 1 972a; Allwood & Asherson, 1973) monitoring of lymphocyte function during and after treatment was considered clinically desirable as well as scientifically important
All patients showed a decrease in lymphocyte count during the first 24 h (0 005 >P> 0.001)
There was a reduction in the mitotic response to PHA at 3 and 24 h after CP administration (Fig. 2)
Summary
The nmean values for all assays at the various times are showiv in the Table. Th-e z values for effector-cell populations in the blood of a large number of healthy donors approximate more nearly to a normal distribution than do the corresponding p values, and all cytotoxicity measurements were transformed to z values for the purposes of statistical evaluation. Results could be expressed as mean z, or converted back to specific cytotoxicity values for presentation. No correction was made for the potential contribution of spontaneous cytotoxicity to that found in cultures containing antibody or PHA. The cells responsible for spontaneous cytotoxicity ("natural killer cells") have not been shown to be identical to those mediating
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