Effect of intravenous combined with oral hydration in the prevention of contrast induced nephropathy in patients with chronic renal insufficiency

Abstract

Objective To compare the effect of intravenous combined with oral hydration and routine hydration in the prevention of contrast induced nephropathy in patients with chronic renal insufficiency. Methods A total of 48 patients who were undergoing percutaneous coronary intervention or diagnosis were randomized divided into the short-time hydration group (25 cases) and the conventional hydration group (23 cases). Patients in the short-time hydration group received intravenous hydration at 3 ml/(kg·h) from 1 hour before the operation to 4 hours after the operation, and oral hydration at 1 ml/(kg·h) rate from 4 hours before the operation to 10 hours after the operation. Patients in the conventional hydration group received intravenous hydration at 1 ml/(kg·h) from 12 hours before the operation to 12 hours after the operation. Levels of Serum creatinine (Scr) and Cystatin C (CysC) were measured 1 d, 2 d and 3 d preoperative and postoperative, and the incidence of contrast induced nephropathy between two groups was statistically analyzed. Results There was no significant difference in blood Scr, CysC of 1 d, 2 d and 3 d preoperative and postoperative and incidence of contrast nephropathy between two groups (P>0.05). Conclusions The effect of short time intravenous combined with oral hydration and routine hydration in the prevention of contrast induced nephropathy has no difference in patients with chronic renal insufficiency. Key words: Renal insufficiency, chronic; Intravenous hydration; Oral hydration; Contrast-induced nephropathy