Effect of intratumoral implantation of barium hexaferrite, magnetite, hematite, aluminium oxide and silica on the dynamics of Erlich tumor growth and survival value of tumor-carrying mice

Abstract

Introduction. We have earlier shown antitumoral effect of barium hexaferrite implant BHF for models of two intratumoral transplantable solid tumor of mice LIO-1 and Erlich (2 sm3 tumors). In the mentioned work on the model of a rather big sized solid Erlich tumor (3 sm3) we have studied a comparative antitumoral effect after the implantation of BHF particles with a residual magnetic field of 150 mGsm referring to particles of iron oxides with residual magnetic field that was nearing to the zerohematite (Fe2O3) and magne tite (Fe3O4), and as well as for the control aluminium oxide (Al2O3) and silica (nSiO2 ∙ mH2O).
 Material and methods. Trials have been conducted with 70 white mice female mice with a mass of 2324 g. Malignant epithelial tumor of Erlich was intramuscularly transplanted into the right hind extremity. When tumors reached a size of 3 sm3, mice were divided into 6 groups whom BHF, magnetite, hematite, aluminium oxide, silica or physiologic saline were implanted, correspondingly.
 Results. As a result of the conducted studies it was found that BHF being implanted into a big-sized tumor (3 sm3) has a mild antitumoral effect for all the studies periods. Particles of iron oxides magnetite and hematite with a magnetic field nearing the zero did not possess the antitumor effect. By the end of experiment (29 days) in all groups including a control group, death of mice at 20 to 50 percent have been seen, and tumors were significantly necrotized, whereas in a group with implantation of silica into the tumor 100 percent of mice have survived and tumors itself did not have necrosis and had even pink colouring.