EFFECT OF INTRATRACHEAL INSTALLATION OF SURFACTANT OH LUNG FUNCTION AND FUNCTIONAL RESIDUAL CAPACITY (FRC) IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS)

Abstract

To understand the mechanism behind improved oxygenation after surfactant in infants with RDS we analysed changes in lung compliance (CL, ml/cmH2O), lung resistance (RL, cmH2O/l/s/cm), overdistention (C20/C1), FRC (ml) and oxygen need (FiO2). Data were collected serially in nine infants (CurosurfR two, ExosurfR seven) (BW: 1389 ± 540 g) prior to and post surfactant treatment. Lung mechanics were determined by a differential pressure transducer and pneumotachography (PEDSR). FRC was measured by a helium dilution technique (PANDAR) with correction for gas leakage. Ventilator settings (except FiO2) were if possible kept constant during the study. (Data given as mean±SEM).Surfactant significantly increases FRC, while lung compliance and resistance (during mechanical breath) do not improve. The improved oxygenation after surfactant treatment is probably related to increased lung volume.