Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy

Abstract

Background and objectivesInterleukin-6 is a predictor of trauma severity. The purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma interleukin-6 after hysterectomy. MethodA prospective, randomized, comparative, double-blind study with 40 patients, aged 18–60 years. G1 received lidocaine (2mgkg−1h−1) or G2 received 0.9% saline solution during the operation. Anesthesia was induced with O2/isoflurane. Pain severity (T0: awake and 6, 12, 18 and 24h), first analgesic request, and dose of morphine in 24h were evaluated. Interleukin-6 was measured before starting surgery (T0), 5h after the start (T5), and 24h after the end of surgery (T24). ResultsThere was no difference in pain severity between groups. There was a decrease in pain severity between T0 and other measurement times in G1. Time to first supplementation was greater in G2 (76.0±104.4min) than in G1 (26.7±23.3min). There was no difference in supplemental dose of morphine between G1 (23.5±12.6mg) and G2 (18.7±11.3mg). There were increased concentrations of IL-6 in both groups from T0 to T5 and T24. There was no difference in IL-6 dosage between groups. Lidocaine concentration was 856.5±364.1ngmL−1 in T5 and 30.1±14.2ngmL−1 in T24. ConclusionIntravenous lidocaine (2mgkg−1h−1) did not reduce pain severity and plasma levels of IL-6 in patients undergoing abdominal hysterectomy.