Abstract
A group of 33 New Zeland rabbits were injected with 4g/kg weight/day of Intralipid (ITL) 20%. They were injected intravenously, intraperitoneally and intragrastically. The aim was to study the variations in plasma and brain lipids after fats overdosages. A control group, which was operated without receiving ITL, was also established. After 15 days of daily Intralipid dosage, complex lipids and fatty acids (FA) administered with ITL rose in plasma levels in the intravenous and intraperitoneal groups. The study of brain lipids showed decreasing levels of phosphatidilethanolamine (PhE), phosphatidilcholine and phosphatidilserine (PhC+PhS), and palmitoil cerebroside (PC) in those groups parenterally supplemented with ITL, without any variation in the polar lipds/neutral lipids ratio ( PL NL ). Those groups supplemented with ITL showed increasing levels of the stearic (C-18) and oleic (C-18:1) acids in brain, whereas linoleic (C-18:2) and arachinodic (C-20:4) acids levels decreased. In conclusion, parenteral Intralipid overdosages cause longer-lasting changes in plasma lipids after intraperitoneal administration. A decreasing level of structural lipids, linoleic and arachidonic acids and also the ratio between both is noticed in the brain affecting all supplemented groups. All these changes in the adult animals are different to the ones described in other animals and lactant humans.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
