Abstract
This study aimed to evaluate the effect of intraarticular injection with platelet-rich plasma on knee osteoarthritis. A total of 250 patients with stages I–III osteoarthritis from December 2018 to June 2020 were included in this study. All the patients had received autologous PRP injection (3 ml) into the affected knee joint every week for totally 3 injections. The VAS score and WOMAC index were used to evaluate knee function before and at 3 days, 1 month, and 3 months after injection. A total of 250 patients were enrolled in this study, including 130 patients in the PRP group and 120 patients in the control group. The content of platelets in PRP of patients in the PRP group was 958.0 ± 283.1 × 109/L. The VAS score and WOMAC index of patients in the PRP group before treatment were not significantly different from those in the control group. At 3 days, 1 month, and 3 months after PRP treatment, the VAS score and WOMAC index of the PRP group were significantly lower than those of the control group. PRP is effective in treatment of knee osteoarthritis. The pain symptoms can be alleviated at 3 days after injection.
Highlights
Knee osteoarthritis is one of the common degenerative diseases in the clinic, especially in people aged more than 65 years and with a high amount of exercise [1]
Platelet-rich plasma (PRP) contains high concentrations of self-derived growth factors, including the vascular endothelial growth factor, plateletderived growth factor, and transforming growth factor β, which promote the proliferation of chondrocytes and the synthesis of extracellular matrix [3–5]
A total of 250 patients were enrolled in this study, including 130 patients in the PRP group and 120 patients in the control group. e baseline conditions of the two groups of patients are given in Table 1. e sex ratios of the two groups of patients were similar, and the ages of the two groups were not much different. ere was no statistically significant difference in the complete blood count between the two groups. e content of platelets in PRP of patients in the PRP group was 958.0 ± 283.1 × 109/L, and the counts of white blood cells and red blood cells in PRP were almost zero. ere was no significant statistical difference in the results of biochemical examinations between the two groups of patients
Summary
Knee osteoarthritis is one of the common degenerative diseases in the clinic, especially in people aged more than 65 years and with a high amount of exercise [1]. Platelet-rich plasma (PRP) is a concentrated polymer with a higher concentration of platelets obtained after autologous blood concentration. PRP contains high concentrations of self-derived growth factors, including the vascular endothelial growth factor, plateletderived growth factor, and transforming growth factor β, which promote the proliferation of chondrocytes and the synthesis of extracellular matrix [3–5]. PRP is easy to prepare, relatively low cost, and high in safety, so it is increasingly used in the field of sports system injuries. There have been clinical studies on the treatment of osteoarthritis by PRP injection, but the curative effect is not consistent. There have been clinical studies on the treatment of osteoarthritis by PRP injection, but the curative effect is not consistent. e possible reason is that the difference in the preparation method results in a large difference in the cellular components of PRP [6]
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