Abstract
Dietary conjugated linoleic acid (CLA) has shown wide biologically beneficial effects, such as anticancer, antiatherosclerotic, antidiabetic, immuno-modulating, and antiobesity effects. However, the effects of CLA on total body ash, reflective of bone mineral content, have not been consistent. We hypothesized that the inconsistency of CLA’s effect on ash may be linked to interaction between CLA and dietary calcium levels. Thus we investigated the effects of CLA on body ash with various calcium levels. 72 male ICR mice were fed 4 different levels of calcium (0.01% to 2 %) with or without 0.5% CLA for 4 weeks. Although there were no differences in body weights and food intake between individual groups, overall CLA fed animals tended to weigh slightly less and consumed less food than control. CLA feeding reduced body fat regardless of dietary calcium level. Increments of calcium beyond the minimal requirement (0.5%) did not improve total ash in control groups. In contrast, CLA supplementation increased body ash compared to control only when the calcium level was higher than 0.5%. This suggests possible beneficial effects of CLA, along with calcium supplementation, on bone mass. Supported by USDA CSREES MAS00919.
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