Abstract
Aim:This study aimed to identify the effect of the insulin-like growth factor 1 (IGF1) gene on growth, to uncover the genetic marker at the IGF1 gene, and to predict growth performance by analyzing growth models of Kejobong goats based on their genotype.Materials and Methods:DNA and records of body weight (BW) and body measurements (BM) of Kejobong goats were collected, the IGF1 gene was amplified from the DNA template by polymerase chain reaction (PCR); the PCR products were then sequenced to determine single nucleotide polymorphisms (SNP). Linear mixed model (LMM) was used to analyze the association between SNP and growth traits. Four non-linear growth models were analyzed using non-LMM to describe the growth model and to compare the growth within genotypes.Results:An SNP at intron 4 (g5752G→C) genotyped into GG and CC was significantly associated with BW and BM. Goats of genotype GG had a significantly higher BW and BM (p<0.05) than those of genotype CC. Growth analysis showed that the von Bertalanffy model was the most fit for describing BW, the Brody model for chest width and hip height, the Gompertz and Logistic models for heart girth, and the von Bertalanffy and Gompertz models for hip width.Conclusion:An SNP at intron 4 of the IGF1 gene was associated with the growth trait and was usable as a genetic marker candidate for improvement of growth traits of Kejobong goats while von Bertalanffy model provides proper and accurate estimates of parameters to describe the growth performance of Kejobong goats.
Highlights
Growth traits have always attracted much interest in the production of meat animals
An single nucleotide polymorphisms (SNP) at intron 4 (g5752G→C) genotyped into GG and CC was significantly associated with body weight (BW) and body measurements (BM)
Growth analysis showed that the von Bertalanffy model was the most fit for describing BW, the Brody model for chest width and hip height, the Gompertz and Logistic models for heart girth, and the von Bertalanffy and Gompertz models for hip width
Summary
Growth traits have always attracted much interest in the production of meat animals. The Kejobong goat is known as an indigenous Indonesian breed raised by a semi-intensive animal farming system by local farmers. This goat has been confirmed to be the progeny of a cross between Kacang and Etawah grade goats [1,2]. The Kejobong goat is known for its prolific traits and for its high rate of growth, good carcass composition, and good reproductive performance [3]. The genetic improvement of Kejobong goats has been slow because only a few genetic studies have been done on its growth traits
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