Abstract
Insulin-like growth factor 1 (IGF-1) is one of the main factors that can affect the condition and rate of skin regeneration process. Morphological and molecular biological investigations were carried out to study skin wounds of wild-type FVB mice and transgenic K14/mIGF-1 animals with streptozotocin-induced diabetes. Increases in the IGF-1 expression, the area and thickness of regenerated epithelium, and number of Mac-1+ cells per wound were shown in transgenic animals compared with wild-type animals.
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