Effect of insulin and phenazine methosulphate on pathways of glucose catabolism in the mammary gland of the rat.

Abstract

THERE is considerable evidence that a large part of the glucose catabolism of the lactating mammary gland of the rat occurs by way of the pentose phosphate pathway1. The effect of insulin on the relationship between glucose utilization and fatty acid synthesis has recently been investigated by Abraham et al. 2, who have shown that the addition of insulin to mammary gland slices from lactating rats caused an increased production of carbon dioxide labelled with carbon-14 from (1−14C)glucose and an increased incorporation of glucose carbon into fatty acids.